Preventing False Positives: Considerations for the Development of Targeted Methodologies

Preventing False Positives in Targeted Analytical Methodologies:
A Must-Read for Analytical Scientists

False positives in nitrosamine analysis can lead to costly missteps and regulatory complications—yet many labs still rely on generic methods that put data integrity at risk.

In this insightful presentation, Nathanael Page of Resolian outlines why a one-size-fits-all approach falls short and how tailored method development can significantly reduce the risk of false positives.

From identifying critical sources of analytical error to exploring the importance of chromatographic selectivity and HRAMS techniques, this document offers a practical, expert-led guide to more accurate, reliable results.

Download the full presentation to explore Resolian’s proven strategies for precision and confidence in nitrosamine testing.

Topics Covered

Strategic Considerations for Adopting Oligonucleotide Therapies

  • Identifying potential sources of false positives during the development of analytical methods.
  • Approaches to mitigate the risk of false positives during the development of analytical methods.
  • Considerations for the utilisation of High Resolution Accurate Mass Spectrometry in confirmatory nitrosamine analysis.

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Zhiyang Zhao, Ph.D.

Chief Scientific Officer

Zhiyang Zhao, Ph.D., serves as Chief Scientific Officer (CSO) at Resolian. Dr. Zhao has over 30 years of pharmaceutical industry experience with special focus on drug metabolism and bioanalysis of small and large molecules in drug discovery and development. Dr. Zhao has previously held positions at Pfizer, GlaxoSmithKline, and Amgen. Before joining Resolian in 2015, Dr. Zhao served as Site Director of Preclinical Research at Amgen in Cambridge, Massachusetts, for over a decade. 

Currently, Dr. Zhao serves as an Adjunct Professor at the Eshelman School of Pharmacy of the University of North Carolina at Chapel Hill, North Carolina, and as Editor-in-Chief of Drug Metabolism & Bioanalysis Letters, a journal by Bentham Science, which publishes in all areas of drug metabolism and bioanalysis. Dr. Zhao received his Ph.D. degree in Medicinal Chemistry from Virginia Polytechnic and State University (popularly known as Virginia Tech) in Blacksburg, Virginia. 

 

Patrick Bennett

Chief Executive Officer

Patrick Bennett has over 35 years of experience in pharmaceutical analysis and laboratory management. Now Chief Business Officer at Resolian, Patrick’s experience includes the roles of Strategic Marketing Director for Pharma with Thermo Fisher Scientific, LabCorp, and Vice President of Strategy and Development with PPD. 

Patrick earned a B.S. degree in Toxicology and a M.S. degree in Pharmacology from the College of Pharmacy and Allied Health at St. John’s University and an M.B.A in International Marketing from the Martin J. Whitman School of Management at Syracuse University.