Drug Metabolism and Pharmacokinetics
ADME / DMPK Services. Supporting early drug discovery and late-stage drug development with state-of-the-art technologies.
Drug Metabolism and
Pharmacokinetics Support
in vitro ADME and biotransformation
to support drug discovery and development.
Expert support for your early discovery to IND enabling and clinical DDI studies.
Customizable DMPK/ADME solutions for seamless drug discovery.
IN VITRO ADME
- Aqueous solubility
- Metabolic stability (microsomes,S9, hepatocytes, recombinant enzymes, plasma, tissue, etc.)
- Blood cell partitioning
- Protein binding (RED, UC, UF)
- Reaction phenotyping (CYP, UGT, CES)
- Permeability (Caco-2 & MDCK) CYP induction & inhibition (Direct & TDI)
- Drug transporter substrate & inhibition (P-gp, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, MATE1, MATE2-K)
- UGT inhibition
- Metabolite identification & profiling in multiple species (in vitro and in vivo)
- MIST assessment development
IN VITRO ADME
- Aqueous solubility
- Metabolic stability (microsomes,S9, hepatocytes, recombinant enzymes, plasma, tissue, etc.)
- Blood cell partitioning
- Protein binding (RED, UC, UF)
- Reaction phenotyping (CYP, UGT, CES)
- Permeability (Caco-2 & MDCK)
CYP induction & inhibition (Direct & TDI) - Drug transporter substrate & inhibition (P-gp, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, MATE1, MATE2-K)
- UGT inhibition
- Metabolite identification & profiling in multiple species
(in vitro and in vivo) - MIST assessment development
IN VIVO RODENT PK
- Commercially available rat and mouse models
- Fast turnaround, cost-efficient, and highly customized solutions
- Comprehensive routes of delivery
(IV, PO, SC, IM, IP, IN, dermal) - Formulation screening
- Sparse and serial sample collection
- Tissue, urine, CSF collection for biodistribution
- PBMC preparation
- Dedicated bioanalytical support for all therapeutic drug modalities
- Non-compartmental analysis using industry standard Phoenix
- WinNonlinTM
Expert advice & consultation
Why work with Resolian?
- Our flexibility allows changes up 24 hours before the start of a study
- Real-time communication with the sponsor
- We provide consistent, dependable, reproducible quality data
- Customized study design and report
Our Drug Metabolism and Pharmacokinetics Resources
