Drug Metabolism and Pharmacokinetics
ADME / DMPK Services. Supporting early drug discovery and late-stage drug development with state-of-the-art technologies.
Drug Metabolism and Pharmacokinetics Support
in vitro ADME, biotransformation and in vivo rodent PK/TK studies to support drug discovery and development.
Expert support for your early discovery to IND enabling and clinical DDI studies.
Customizable solutions for seamless drug discovery. Comprehensive DMPK/ADME Services.
IN VITRO ADME
- Aqueous solubility
- Metabolic stability (microsomes,S9, hepatocytes, recombinant enzymes, plasma, tissue, etc.)
- Blood cell partitioning
- Protein binding (RED, UC, UF)
- Reaction phenotyping (CYP, UGT, CES)
- Permeability (Caco-2 & MDCK)
CYP induction & inhibition (Direct & TDI) - Drug transporter substrate & inhibition (P-gp, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, OCT1, MATE1, MATE2-K)
- UGT inhibition
- Metabolite identification & profiling in multiple species
(in vitro and in vivo) - MIST assessment development
IN VITRO RODENT PK
- Commercially available rat and mouse models
- Fast turnaround, cost-efficient, and highly customized solutions
- Comprehensive routes of delivery
(IV, PO, SC, IM, IP, IN, dermal) - Formulation screening
- Sparse and serial sample collection
- Tissue, urine, CSF collection for biodistribution
- PBMC preparation
- Dedicated bioanalytical support for all therapeutic drug modalities
- Non-compartmental analysis using industry standard Phoenix
- WinNonlinTM
Expert advice & consultation
