Large Molecule LC-MS/MS
Complex Biologics. Confidently Quantified.
Reagent-free, mass-based bioanalysis for antibodies, proteins, peptides, and ADCs, from method development to GxP validation.
To best align with targeted assays for your biologic or large molecule therapeutics, developed assays can quantify intact large molecules and their metabolites directly or through signature peptide(s) using LC-HRAM or LC-MS/MS methods.
These are robustly established with high sensitivity by implementing proven extraction and purification techniques, coupled with options of bottom-up proteolytic digestion or top-down intact analysis.
These molecules include
- Antibodies/ADC
- Native/recombinant proteins
- Peptides/PDC
Reach out to us directly to learn more about Resolian’s Large Molecule LC-MS/MS services.
Global capabilities for large molecule LC-MS/MS assays.
Featured Techniques and Strategies
- Reagent free assays: Faster project progression and a translatable assay format through drug development
- Mass-based detection: Overcome challenges associated with non-specific immunoassay reagents (immunoassay can be hybridized to LC-MS for greater sensitivity)
- Ability to resolve closely related species: Provide structural information on the fate/stability of the protein
- Complementary to immunoassay: Can offer a simpler route to a “total” assay
- Possibility to multiplex analytes: Multiple proteins or multiple surrogate peptides from a single protein can be monitored through a single measurement
Ready to accelerate your biologic or large molecule programme?
Partner with a bioanalytical specialist that resolves the complexity of large molecule quantification: from intact analysis
and signature peptide strategies to full regulatory compliance.
Our Bioanalytics Resources
Case Studies
Measuring What Matters: High-Precision Plasma Protein Binding Assessment for Highly Bound Compounds Under ICH M12
Case Studies
Solving Carboplatin: A Novel LC-MS/MS Assay for Intact Drug Quantitation in Human Plasma
Case Studies
Developing and Validating a Simple, Rapid LC-MS/MS Method for Semaglutide in Human Plasma
Case Studies
Overcoming Bioanalytical Challenges in siRNA Oligonucleotide Quantitation by LC-MS
News, Blog
Empowering Early-Career Scientists: Jennifer Hawkins’ Journey at the REID Bioanalytical Forum
Our Labs – Large Molecule LC-MS/MS
America
Kingdom
Choose a location
United Kingdom
Bioanalytics Fordham
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Protein and oligonucleotide LC-MS
- Immunogenicity
- Flow cytometry
+ Over 25 years of experience in Europe
Learn MoreAnalytical Sciences Fordham and Sandwich
Your specialist in:
- GMP and CMC testing
- Materials Science
+ Over 20 years of experience in Europe
See Fordham LabSee Sandwich Lab
North America
Bioanalytics Malvern
Your experts in:
- LC-MS
- Immunoassay
- Protein and oligonucleotide LC-MS
- Immunogenicity
- Biomarkers
- DMPK
- PCR
+ Over 15 years of experience in the US
Learn MoreAustralia
Bioanalytics Brisbane
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Early phase clinical research/phase I studies
Specialists in Australia
Learn MoreChina
Bioanalytics Chongqing
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Protein and oligonucleotide LC-MS
- Antibody Drug Conjugates
- mRNA assays
+ Over 20 years of industry experience
Learn More
