When Compliance Meets Sustainability Challenges
Your laboratory needs to verify vitamin content across diverse supplement formulations – tablets, capsules, inhalation devices – to ensure products contain labeled amounts and meet GMP requirements.
The challenge? Traditional analytical methods consume large quantities of toxic organic solvents and generate significant hazardous waste. Over months and years of routine use, these methods create substantial environmental impact and disposal costs.
You need accuracy and regulatory compliance.
But increasingly, you also need sustainability.
Watch: A Greener Approach to Vitamin E Analysis
In this video, Resolian analytical scientist Matthew Knox presents a platform solution that addresses both requirements: Supercritical Fluid Chromatography (SFC-UV) for GMP analysis of vitamin E across multiple supplement matrices.
The environmental footprint of analytical laboratories is substantial—high energy demands, continuous solvent consumption, and ongoing hazardous waste disposal. As the industry moves toward greener practices, the methods we choose matter not just for weeks, but for the entire lifecycle of routine analysis.
Matthew’s presentation demonstrates how SFC technology fundamentally changes this equation.
What You’ll Learn in This Video:
- Why vitamin supplement testing requires robust, validated analytical methods
- How Supercritical Fluid Chromatography uses pressurized CO₂ as mobile phase
- The environmental advantages of SFC versus traditional liquid or gas chromatography
- How one platform method analyzes tablets, capsules, and inhalation devices
- The flexible sample extraction workflow that enables multi-matrix analysis
- Real-world application of green analytical chemistry principles in GMP environments
By using pressurized carbon dioxide instead of toxic organic solvents, SFC delivers the separating power needed for complex analyses while dramatically reducing environmental impact. Combined with thoughtful extraction workflows, this becomes a true platform approach—one method serving multiple formulation types.
Why Platform Methods Matter
Beyond the immediate sustainability benefits, platform methods offer practical advantages for analytical laboratories:
- Reduced method development time for new formulations
- Simplified validation and transfer between sites
- Lower training requirements with standardized procedures
- Decreased inventory of solvents and reagents
- Consistent results across diverse matrices
The platform approach demonstrates that green chemistry isn’t just about individual experiments—it’s about designing sustainable workflows that serve laboratories for years.
Green Chemistry Without Compromise
The pharmaceutical and supplement industries face increasing pressure to reduce environmental impact while maintaining rigorous quality standards. These goals are often presented as competing priorities.
Resolian’s work with SFC methodology shows they’re not. Advanced separation techniques like supercritical fluid chromatography enable laboratories to meet GMP requirements while genuinely reducing their environmental footprint—not through compromise, but through innovation.
Partner in Sustainable Method Development
Transitioning to greener analytical methods requires more than new equipment—it requires expertise in method development, validation, and regulatory compliance within evolving sustainability frameworks.
Resolian’s analytical sciences department specializes in developing sustainable analytical solutions that meet stringent GMP requirements. Our team understands both the chemistry and the compliance landscape, enabling us to design methods that serve your quality needs while supporting your environmental commitments.
Whether you’re looking to reduce solvent consumption, develop platform methods for multiple matrices, or explore greener alternatives to conventional chromatography, we bring the expertise to make sustainability practical.
Ready to explore sustainable analytical solutions?
Contact our analytical sciences team to discuss how SFC and other green chemistry approaches can support your laboratory’s goals.
